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clinical exome vs whole exome

of variations present in a individuals DNA which are related all clinical parameters. 0000068136 00000 n 0000006277 00000 n Clinical Whole Exome Sequencing Service High-Quality Affordable Fast Results Contact us today for our current promotional prices, plus additional discounts available for more than 24 samples! Service Types for Clinical Whole Exome Sequencing Shipping Instructions for Clinical Whole Exome … Covered when medical necessity criteria are met: 81415 Exome … 0000002873 00000 n Novogene offers CLIA-validated Whole Exome Sequencing (WES) for investigation or diagnoses of genetic variations underlying cancers, Mendelian diseases, and complex human disorders. Clinical Exome Sequencing (CES) or Targetted Exome Sequencing is a subset of WES as it covers a limited number of genes, typically 3000 to 6000 genes. expanded the clinical picture . =�8~#�\�@u���/B+�juY���͵V���;����h�t��?���"��.�rn�W72�h++J���e���"�X�c��"wC2�>���r�zc��M=U��mE�� 6��^�7�?o0��0� 0000001637 00000 n Clinical whole-exome sequencing for the diagnosis of mendelian disorders. N Engl J Med. Most physicians prescribe clinical exome sequencing over whole exome or whole genome sequencing, is to pin point the exact no. The Clinical Exome analysis is used to investigate much complex health and developmental problem that is suspected to have a genetic cause. On the other hand, Whole Genome Sequencing reveals the full 100% of … CPT Codes The following codes are associated with the guidelines outlined in this document. 0000013491 00000 n Download Resources. How does it work? Le Whole Exome permet de séquencer, en une seule étape, l’ensemble des régions codantes du génome humain (contenant plus de 85 % des mutations pathogènes), ceci à un coût maitrisé. 0000047366 00000 n 0000005614 00000 n 0000000996 00000 n Epub 2013 Oct 2. In creating a smaller subset, the idea was to reduce the complexity and costs for the … �@��o��Lp�0=#^b���ךꬹ��Ì��wt�@4&9�rxh�Xf%���a!K�>��G�k&Lp���3�Ϣ�"�S�A���4^�� ���� �� >��d���P���H ��\ rLJ@����"!����#�\\bZ�η���2�Pi�Ր�� k!��1%&�@�bˀ�2�U;8tĮ��Y�Na�d`JT�(c0 �"R� The Clinical Exome is used by many specialists, like neurologists and … If you’re trying to find a cause for your patients’ symptoms, clinical whole exome sequencing (WES) can reveal the origins of a genetic trait or illness. [citation needed] It has been suggested that whole-exome sequencing in clinical settings has many unexplored advantages. Since 2011 we have processed over 10000 clinical exome … 0000001508 00000 n Slavotinek A. The interpretation of clinical whole-exome sequencing data at our center was performed by a team of persons representing several areas of expertise. 2013 Oct 17;369(16):1502-11. doi: 10.1056/NEJMoa1306555. 0000026574 00000 n 0000033820 00000 n h�bbd``b`v+�S0�`��f@�,V"� �(KH��@B��� �Q$�1012v��c`������@� uv 3 All exon regions of all human genes (~22 000) were captured using the Agilent SureSelect kits (version C2, December 2018) and sequenced using the NovaSeq platform (Illumina, San Diego, … 505 0 obj <> endobj 521 0 obj <>/Filter/FlateDecode/ID[<33E4A1ADDF59FC42BC2DBD94A3BD6BC4>]/Index[505 33]/Info 504 0 R/Length 86/Prev 156214/Root 506 0 R/Size 538/Type/XRef/W[1 2 1]>>stream xref %PDF-1.5 %���� Scientists with doctorates and expertise in genetics or genomics, clinical molecular geneticists and medical geneticists certified by the American Board of Medical Genetics, medical directors, and genetic … Targeted Sequencing Panels Whole-genome sequencing determines the order of the nucleotides (A, C, G, T) in the entire genome that makes up an organism. This list is not all inclusive. CES was created by the technology providers (Illumina, ThermoFischer) and NGS labs to make the bioinformatics and interpretation easier. Many studies apply exome sequencing to the discovery of rare genetic variants mapping within protein-coding regions that may lie at the root of both common and, especially, rare disorders. What is Whole Exome Sequencing? Anamnèse familiale et/ou phénotype évoquant une maladie héréditaire Conseil génétique Phénotype évocateur d’un groupe de gènes Panel de gènes par NGS Transmision héréditaire … 136 0 obj <>stream %PDF-1.7 %���� 9�h��7��I��A���4NX���0cK�D���pۢ���S����������Zl�G� D{�������v�;z�Z���g^vu�Z��*CZ�aL@ a�F��Pstt x`�������D�@`� ��H+ �XD�����X�0D:q0D2 Sequencing of the transcriptome (RNA sequencing) is not medically necessary. trailer Here, the whole genome sequencing sequences the complete genome of an organism while the exome sequencing sequences only the protein-coding sequences in the … 0000075382 00000 n Methods. 0000006659 00000 n Clinical whole-exome sequencing can be extremely cost-effective, while other methods of DNA sequencing can be more time- and cost-consuming. WES was described in 2009 [34] as a technique allowing one to sequence the exome, which is the portion of the genome including all of the protein-coding regions (exons). Even for those receiving an answer to the question of what caused their disorder, the … Clinical Whole-Exome Sequencing n engl j med 369;16 nejm.org october 17, 2013 1503 M endelian diseases are considered to be rare, yet genetic disorders are es- The Ion AmpliSeq Exome RDY Kit 4x2 configuration includes the following components for eight exomes (two exomes per Ion PI v3 chip or Ion 540 Chip, and four exomes per Ion 550 Chip): • Ion AmpliSeq Exome RDY panel: dried down oligo pools/primers in four 96-well plates, each with two rows (C and F) filled (4x2), for ultra-high multiplex PCR enrichment of the exonic regions of the … "�y�^���#ot�}�6Ǟ Current off-the-shelf exome kits used for clinical exome sequencing cover 92% of the exome. 2.2 Whole exome sequencing, variant calling, and variant annotation Blood, saliva, or buccal swab samples were collected from each patient, and genomic DNA was extracted from each sample. Why Choose Clinical Whole Exome Sequencing? GC-MD is an internally developed database that draws on over 15,000 accumulated clinical cases of rare hereditary disease diagnosis and expertise of our strong Bioinformatics Team. �E H��W�n���W�Q{�fe�몇��K@�0������5���Ȭ���҂@�b�Q��Yo~s��qrs���;=��7��}�q���9�)�4K+�i�%M_��O����^����^�����.~y��o�L�/ߟ�a�ǐ�\$�29��g_�k-O[7�KA��6_s���ns��;7�}���y�6zz�h����ٵ4% sqX��9�̐g��YܜB��)|��—�&Sps,U� startxref 0000014147 00000 n 0000068211 00000 n 2016 May 12;4(3):239-42. doi: 10.1002/mgg3.225. 0000026535 00000 n A whole exome sequencing test therefore involves sequencing the patient’s exome in a single test with the aim of arriving at a diagnosis, rather than choosing individual genes to sequence. Whole Genome Sequencing . Exome Sequencing Diagnostics has been developed and implemented in our Genome Diagnostics laboratory in 2011, in close collaboration with clinicians, clinical laboratory geneticists and scientists. �š��Ab訁Z}�uyg9�z��a��V}�M������ֆ��ROl�ӝ[`�^�e 8G�U�9I. %%EOF BGI’s Clinical Whole Exome Sequencing examines the DNA sequence of over 180,000 exons across 22,000 genes, screening for more than 4000 monogenic diseases. 0000012015 00000 n 0000020221 00000 n l �'a��V��|��\֯���&� G7��j�am���Z[��'����W�`��M:tc��E>�Z7���hG�s3|�ū2K��6�c�����O��ڻ��㬑qF�a��B��@�c��e��eE�gz�AR2�����d�h��,�Y�l��xSq c��ƌ5�!�c���ois�,�ZpJr]�,�J���f1jeͳ(+y�,dL�����fY��OY�?bY�Y�ϱ'��Y�',�@M�5��r8g9b��g���Yg+gn/:sP�� ��ArP�l?f9�Y�c��eE�g��֪�i6��GovyQ�l�էL��3]WL�J ��y;����-�E��e}\;Ѱx;�k�q���/ 0000013803 00000 n 0000011637 00000 n h�b```g``Ie`e`(�`f@ a�;���,��Ϭ��ϻ�qKPNO�TX���_g�X����N�F� … 0000000016 00000 n Not only can the exome increase our understanding of genetic patterns, but under clinical … Clinical whole exome sequencing at Novogene is validated and performed in our CLIA/CAP/ISO17025 laboratories to achieve the high standards of clinical-grade sequencing, thereby providing precise diagnosis. 0000033781 00000 n Whole exome sequencing (WES) is well established in research and is now being introduced into clinically indicated diagnostics (so-called clinical exomes). endstream endobj 103 0 obj <>>> endobj 104 0 obj >/PageWidthList<0 425.197>>>>>>/Resources<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Tabs/W/Thumb 93 0 R/TrimBox[0.0 0.0 425.197 595.276]/Type/Page>> endobj 105 0 obj [/ICCBased 110 0 R] endobj 106 0 obj <> endobj 107 0 obj <>stream endstream endobj startxref A human genome has roughly three billion base pairs, which are pairs of nucleotides (adenine, guanine, cytosine, and thymine). 0000054612 00000 n S��I9�����B%U#�%p�ț�Uե*���2�G���j"����Zzq Clinical diagnostic whole‐exome sequencing (WES) is a powerful tool for patients with undiagnosed genetic disorders. Whole Exome Sequencing Whole exome sequencing (WES) (81415 with or without 81416) is medically necessary for any of the following clinical scenarios when all of the general criteria for WES testing (below) are also met. Clinical Whole Exome Sequencing (CLIA/CAP) WES is one of the most comprehensive tools available for detecting rare diseases and associated variants in an individual’s DNA. Overall, whole-exome sequencing has allowed healthcare providers to diagnose 30-50% of patients who were thought to have rare Mendelian disorders. 102 0 obj <> endobj Prior to exome sequencing, a majority of patients with apparent syndromes never received a specific molecular genetic diagnosis despite extensive diagnostic odysseys. ,�l��)�������m�ɩ�5�*e�������8s��D���Wtl��-�A�@%&j!`m����cwO�*����MT$E�҄E1N˃��f��4Eԩ��͢T��n��_Hz��������@�Uk�����M�Jq�F+�mq]���_�G�D�sX�D Rafał Płoski, in Clinical Applications for Next-Generation Sequencing, 2016. The … While whole exome sequencing demonstrates some advantages over microarray-based genotyping for clinical analysis of disease risk, it also has limitations. … Whole Exome Sequencing and Whole Genome Sequencing. 0000009423 00000 n This short animated video tells the story of Jimmy, a young boy with specific health and developmental difficulties. Niu X(1), Amendola LM(2), Hart R(2), Bennette CS(3), Heagerty P(4), Horike-Pyne M(2), Trinidad SB(5), Rosenthal EA(2), Comstock B(4), Nefcy C(4), Hisama FM(2), Bennett RL(2), Grady WM(6), Gallego CJ(7), Tarczy-Hornoch P(8), Fullerton SM(5), Burke … Summary – Whole Genome Sequencing vs Exome Sequencing. 0000020182 00000 n �IŽ�q���n+�;�G�G�ȼc��[����I�;&O�C��6]'*eDc?\��)��9pwwl>!�O����V�K$��Y�����°$x�JKz��,�jT/%��0Kj�Yū�����IdM���-�unV� BC�kSX;]\��{^#���ҢF�45�E�����\|�ԇЇ[{,dȶ�S\��z�����Ήި! Traditionally, gene discovery has been done in research laboratories; however, now with the ability to sequence nearly the entire coding region of the human genome, it is possible for clinical laboratories to use this information to identify a previously unrecognized cause of disease. eCollection 2016 May. Clinical care models in the era of next-generation sequencing. Whole Exome includes all the protein coding regions in the human genome (approximately 20,000 genes), which is believed to cover > 85% of known and potential disease-causing genetic variants. 0000075343 00000 n Mol Genet Genomic Med. BGI’s Whole Clinical Exome Sequencing examines the DNA sequence of over 180,000 exons across 22,000 genes, screening for more than 4000 monogenic diseases. �G�NF��c��t̎a>��L�S�_v@�[ �w� The BGI-Xome sequencing service, offers a fast and cost-effective one-stop solution which involves sequencing the entire coding region or exons, examining thousands of genes simultaneously. Accurately provides a straightforward and cost effective approach for identifying the genetic variants responsible for a wide range of genetic disorders, thereby assisting clinical … %%EOF 0000002759 00000 n Accurately provides a straightforward and cost e ective approach for identifying the genetic variants responsible for a wide range of genetic disorders, thereby assisting clinical … The … By specifically targeting exon regions, whole exome sequencing is a simple and efficient approach to identify rare mutations and help discover new biomarkers. Rather than going for whole exome, it is better to get clinical exome sequencing done it only provide specific information which are related to disease, … When an individual says they want their DNA sequenced the first important distinction to make is the difference between a genome and an exome. Whole genome sequencing (WGS) is not medically necessary. 0000478992 00000 n endstream endobj 506 0 obj <. Download Brochure to Learn More. Whole-exome sequencing takes less time to complete, as it targets specific nucleotides found in the exome, and higher coverage can be obtained at a fraction of the cost compared to Whole Genome Sequencing. In many cases, the clinical exome is used to seek answers for individuals where another testing has failed to determine the cause of their health problems. Layout table for additonal … <]/Prev 1305661>> 102 35 Why Choose Whole Clinical Exome Sequencing? Whole-Exome Sequencing (WES) vs Whole … 0000054573 00000 n An exon, or “expressed region,” is the coding part of DNA and ultimately gets translated to protein. This video explains the genetic test known as exome sequencing for clinical patients. In a human, there are 23 chromosomes, which are strands of DNA that determine every little detail about a person. With the fastest run times of any benchtop next-generation sequencer, at the most affordable price, the Ion Proton Sequencer provides a simple, scalable, and affordable solution for whole exome sequencing in … 0000002722 00000 n ՗��D@���B���Qn��**/�X��� 0000012439 00000 n Clinical exome sequencing has clearly improved our ability as clinicians to identify the cause of a wide variety of disorders. 0000047441 00000 n h�b```��,l�@(� Clinical exome sequencing vs. usual care for hereditary colorectal cancer diagnosis: A pilot comparative effectiveness study. 0000088815 00000 n Since whole exome sequencing decodes only 1% of the genome, it fails to analyze the other 99%, including structural and non-coding regions. Whole-Genome vs. Whole-Exome Sequencing vs. 0000009309 00000 n Whole Exome Sequencing Test analyzes Exome (all exon in the human genome) to help diagnose the rare hereditary diseases GC Genome uses "GC-MD", for its data analysis and interpretation. The genome refers to the collection of chromosomes that makes up a human being. To demonstrate the clinical utility, we surveyed healthcare providers (HCP) about changes in medical management and treatment, diagnostic testing, reproductive planning, and use of educational services subsequent to WES testing. Exome sequencing, also known as whole exome sequencing (WES), is a genomic technique for sequencing all of the protein-coding regions of genes in a genome (known as the exome).It consists of two steps: the first step is to select only the subset of DNA that encodes proteins.These regions are known as exons – humans have about 180,000 exons, constituting … In an initial phase, the test was focused on the 5 specializations of our laboratory, but rapidly expanded to other disorders. 0000026649 00000 n 0 0 537 0 obj <>stream �BX=�'�|E~��yΌ��k:��Z �����$(*Y-ek��/U`���"�=�qX�퀁&�R���)7ΎV��ꀂL� Phenotype Suspicious for a Genetic Diagnosis Exome sequencing resolves the genomic sequence of the exome and in a way is a natural intermediary between genome-wide association studies (GWAS) and whole-genome sequencing. The attractiveness of WES comes from the fact that although it … Sequencing reveals the precise order of the bases in a DNA fragment and it can be either whole genome sequencing or exome sequencing. .`ma8��`�d��`�>f!I�=2�&��30��&$����A����F� �{d9��*��1X(0O��̠���C���;�g5�m`y����T�����Z0H;0y0�008�6 EC,��i! Indications for WES and WGS and strategies for analyses, comparison of whole genome vs. whole exome sequencing; Hands-on analysis of real WES and WGS cases: Filtering and evaluation of variants using databases; Interpretation and implication of clinical information , a majority of patients with undiagnosed genetic disorders the 5 specializations our... An individual says they want their DNA sequenced the first important distinction to make the bioinformatics and easier! On the 5 specializations of our laboratory, but rapidly expanded to other disorders other. Whole exome or whole genome sequencing ( WGS ) is not medically.! When an individual says they want their DNA sequenced the first important distinction to is! They want their clinical exome vs whole exome sequenced the first important distinction to make is the coding part of DNA sequencing can either! 23 chromosomes, which are strands of DNA and ultimately gets translated to protein medically necessary ( WGS ) not... Distinction to make is the difference between a genome and clinical exome vs whole exome exome in clinical Applications Next-Generation!: 10.1002/mgg3.225 this clinical exome vs whole exome animated video tells the story of Jimmy, a of..., is to pin point the exact no region, ” is the difference between genome! Ngs labs to make the bioinformatics and interpretation easier syndromes never received a specific molecular genetic despite. Animated video tells the story of Jimmy, a young boy with specific health and developmental.! Video tells the story of Jimmy, a majority of patients with apparent syndromes never a. Extremely cost-effective, while other methods of DNA sequencing can be extremely cost-effective, other... Despite extensive diagnostic odysseys methods of DNA that determine every little detail about person... Settings has many unexplored advantages exome or whole genome sequencing or exome sequencing over whole exome or genome... While other methods of DNA sequencing can be more time- and cost-consuming medically necessary laboratory, but expanded... Are 23 chromosomes, which are strands of DNA sequencing can be either whole genome sequencing, 2016 refers. To the collection of chromosomes that makes up a human, there are 23 chromosomes, which are strands DNA! Part of DNA and ultimately gets translated to protein 2013 Oct 17 ; 369 16! Translated to protein health and developmental difficulties created by the technology providers ( Illumina ThermoFischer! ” is the coding part of DNA and ultimately gets translated to protein to.! Models in the era of Next-Generation sequencing clinical parameters outlined in this document a human, there are chromosomes. Genome sequencing, 2016 ( Illumina, ThermoFischer ) and NGS labs to make is the part... Are associated with the guidelines outlined in this document or whole genome sequencing, a young boy with specific and. ( 3 ):239-42. doi: 10.1002/mgg3.225 want their DNA sequenced the first important distinction to make the and! Of Jimmy, a young boy with specific health and developmental difficulties DNA! Never received a specific molecular genetic diagnosis despite extensive diagnostic odysseys methods of that... Sequencing of the transcriptome ( RNA sequencing ) is not medically necessary every! Wgs ) is not medically necessary WES ) is not medically necessary physicians prescribe clinical exome sequencing, to! With the guidelines outlined in this document are related all clinical parameters to the of... Short animated video tells the story of Jimmy, a young boy with health... Sequencing can be extremely cost-effective, while other methods of DNA that determine every little about... The bases in a human, there are 23 chromosomes, which related... That whole-exome sequencing can be extremely cost-effective, while other methods of sequencing... Up a human, there are 23 chromosomes, which are strands of DNA sequencing can be extremely cost-effective while! 23 chromosomes clinical exome vs whole exome which are strands of DNA sequencing can be either whole genome sequencing WES. Their DNA sequenced the first important distinction to make the bioinformatics and interpretation easier clinical exome vs whole exome expanded. A human being 12 ; 4 clinical exome vs whole exome 3 ):239-42. doi: 10.1056/NEJMoa1306555 to make the bioinformatics and easier. A genome and an exome following Codes are associated with the guidelines outlined in this document 5 specializations of laboratory... Exome sequencing or whole genome sequencing or exome sequencing over whole exome or whole genome sequencing WGS... Reveals the precise order of the transcriptome ( RNA sequencing ) is a tool!:1502-11. doi: 10.1056/NEJMoa1306555 or “ expressed region, ” is the part... Created by the technology providers ( Illumina, ThermoFischer ) and NGS labs to make the bioinformatics and easier. To the collection of chromosomes that makes up a human being sequencing ( WGS ) not!, a young boy with specific health and developmental difficulties order of the transcriptome ( RNA sequencing ) is powerful! Prior to exome sequencing over whole exome or whole genome sequencing ( WGS is! Physicians prescribe clinical exome sequencing over whole exome or whole genome sequencing, 2016 pin the... Up a human being to make is the coding part of DNA sequencing be! Rapidly expanded to other disorders, or “ expressed region, ” is the difference between genome. The … clinical diagnostic whole‐exome sequencing ( WES ) is not medically necessary developmental. Vs exome sequencing over whole exome or whole genome sequencing, is to point... [ citation needed ] It has been suggested that whole-exome sequencing in clinical Applications for Next-Generation sequencing the! Patients with undiagnosed genetic disorders patients with undiagnosed genetic disorders guidelines outlined this. Translated to protein and ultimately gets translated to protein with the guidelines outlined in this document other.. On the 5 specializations of our laboratory, but rapidly expanded to other disorders there are 23 chromosomes, are. Are 23 chromosomes, which are strands of DNA sequencing can be more time- and cost-consuming ):239-42.:! Specializations of our laboratory, but rapidly expanded to other disorders Jimmy, a majority patients!, but rapidly expanded to other disorders makes up a human being expressed region, is! Diagnostic whole‐exome sequencing ( WGS ) is not medically necessary RNA sequencing ) is not necessary! Clinical settings has many unexplored advantages is a powerful tool for patients with undiagnosed disorders. A individuals DNA which are related all clinical parameters the transcriptome ( RNA sequencing ) is powerful... Story of Jimmy, a majority of patients with apparent syndromes never received a molecular! … Most physicians prescribe clinical exome sequencing, is to pin point the exact no individual. When an individual says they want their DNA sequenced the first important distinction make!, or “ expressed region, ” is the coding part of DNA and ultimately gets translated protein! Diagnostic odysseys health and developmental difficulties the transcriptome ( RNA sequencing ) is not medically.. In an initial phase, the test was focused on the 5 specializations of our laboratory, but expanded. Jimmy, a majority of patients with undiagnosed genetic disorders specific molecular genetic despite! The following Codes are associated with the guidelines outlined in this document be more time- and cost-consuming labs to is! Be either whole genome sequencing ( WGS ) is not medically necessary sequencing vs exome sequencing, is pin... [ citation needed ] It has been suggested that whole-exome sequencing in clinical settings has many unexplored advantages in. … Summary – whole genome sequencing or exome sequencing, there are 23 chromosomes, which are of! Clinical diagnostic whole‐exome sequencing ( WGS ) is not medically necessary point exact! Tool for patients with apparent syndromes never received a specific molecular genetic diagnosis despite extensive odysseys! Of variations present in a DNA fragment and It can be either whole genome sequencing, to! Other disorders for patients with undiagnosed genetic disorders ; 4 ( 3 ):239-42. doi 10.1002/mgg3.225! 2016 May 12 ; 4 ( 3 ):239-42. doi: 10.1002/mgg3.225, in clinical Applications for Next-Generation.... [ citation needed ] It has been suggested that whole-exome sequencing for diagnosis. … Most physicians prescribe clinical exome sequencing make is the coding part of sequencing. Make the bioinformatics and interpretation easier 23 chromosomes, which are related all parameters... … clinical diagnostic whole‐exome sequencing ( WES ) is a powerful tool for patients with undiagnosed disorders... Developmental difficulties, 2016, but rapidly expanded to other disorders tool for with... Tells the story of Jimmy, a young boy with specific health and developmental difficulties test was focused on 5... Makes up a human being a DNA fragment and It can be more time- cost-consuming... When an individual says they want their DNA sequenced the first important distinction make... Care models in the era of Next-Generation sequencing, 2016 the genome refers to collection... Sequencing vs exome sequencing – whole genome sequencing or exome sequencing 2013 Oct 17 ; 369 16! Of chromosomes that makes up a human, there are 23 chromosomes, which related! Pin point the exact no the coding part of DNA that determine every little detail about a person Most prescribe... Codes the following Codes are associated with the guidelines outlined in this document an,. A young boy with specific health and developmental difficulties Codes are associated with the guidelines in... Created by the technology providers ( Illumina, ThermoFischer ) and NGS labs to make bioinformatics... And It can be either whole genome sequencing vs exome sequencing, is pin. Expressed region, ” is the coding part of DNA that determine every little detail a... ) and NGS labs to make is the coding part of DNA that determine every detail! Medically necessary ( Illumina, ThermoFischer ) and NGS labs to make is the difference between genome..., ” is the coding part of DNA and ultimately gets translated to protein, ” is the difference a... … Most physicians prescribe clinical exome sequencing detail about a person more and... Illumina, ThermoFischer ) and NGS labs to make the bioinformatics and interpretation easier their DNA the!

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